Effect of aqueous extract of the leaves of Baccharis trimera on the proliferation of hepatocytes after partial hepatectomy in rats

Abstract Purpose: To evaluate the effect of aqueous extract of Baccharis trimera leaves on the proliferative capacity of the liver after partial hepatectomy (PH) in rats. Methods: Twenty Wistar rats weighing between 300 and 450g were divided into two groups: control (HP) and test (HP100-rats that received the aqueous extract of Baccharis trimera for four days at a dose of 100 mg / kg / day). On the fifth day, animals from both groups underwent resection of 70% of the liver. Twenty-four hours later, they were sacrificed and the remnant liver was removed and prepared for studied through PCNA immunohistochemistry. Data analysis for comparison between the two groups was made through the non-parametric statistical test Mann-Whitney test. Results: In all the animals studied was found most abundant nuclear immunostaining positive hepatocytes interlobular located in regions of the liver. Quantitative analysis of PCNA-positive cells revealed positivity rate significantly higher mean (p = 0.02) in HP100 group (77.1 ± 13.6) compared to the HP group (45.8 ± 12.9). Conclusion: DAdministration of aqueous extract of the leaves of Baccharis trimera 100 mg/kg of animal has a significant positive effect on liver regeneration in rats, 24 hours after hepatectomy (70%).

The effect of the aqueous extract Peumus boldus on the proliferation of hepatocytes and liver function in rats submitted to expanded hepatectomy

ABSTRACT PURPOSE: To assess the effect of aqueous extract of Peumus Boldus (AEPB) on the liver proliferative response after parcial hepatectomy of 70% (PH) in rodents. METHODS: Twenty Wistar rats were divided in two groups: AEPB100 (whose rats received 100mg/Kg of AEPB, once a day, orally, in 4 days prior to the first surgical procedure) and Vehicle (whose rats were treated similarly with distilled water). Both groups underwent PH. After 24 hours the remaining livers were removed for studying the proliferation of hepatocytes by Ki-67 and 2mL of blood were collected for serological assessment: cholesterol, glucose, triglycerides, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and total, direct and indirect bilirubin. All data were analyzed by Gaussian distribution. Statistically significant differences between mean values were analyzed using T Student's test. Non-Gaussian data were analyzed using Mann-Whitney's test. RESULTS: The liver of all these rats presented positive staining of Ki-67, indicating liver proliferation. Laboratory results showed no significant difference in serum values between the analyzed groups. The analysis of Ki-67 was significantly more positive in AEPB100 group than in Vehicle group. CONCLUSION: Aqueous extract of Peumus Boldus acute administration exerts significant positive effect on liver regeneration after 24h in rats that underwent parcial hepatectomy, while maintaining unchanged hepatic function.

A síndrome de burnout em profissionais da Rede de Atenção Primária à Saúde de Aracaju, Brasil / Burnout syndrome in professionals of the primary healthcare network in Aracaju, Brazil

ResumoA Síndrome de Burnout (SB) é decorrente da tensão emocional crônica vivenciada pelo trabalhador, caracterizada por exaustão emocional, despersonalização e baixa realização pessoal. Pode acometer profissionais cuja atividade requeira contato direto com o público. Objetiva-se avaliar a prevalência da SB e fatores associados em profissionais de nível superior vinculados à Rede de Atenção Primária à Saúde do município de Aracaju/SE. Estes profissionais responderam o questionário sociodemográfico e o Inventário de Maslach para o Burnout. A idade média foi de 44,9 anos, maioria enfermeiros, mulheres, casados com filhos e pós-graduação. A prevalência da SB foi de 6,7% a 10,8%, os fatores associados foram idade mais jovem, carga horária de trabalho excessiva e insatisfação profissional. Não houve diferença entre as categorias avaliadas e a maioria não apresenta a SB. No entanto, 54,1% apresentaram um risco elevado e moderado para desenvolver essa síndrome, refletindo um processo de adoecimento que ameaça o bem-estar dos profissionais de nível superior da Rede de Atenção Primária à Saúde de Aracaju – SE. Esses achados sugerem a importância da implantação de medidas preventivas e interventivas voltadas a esses profissionais, de forma a garantir uma melhoria no ambiente de trabalho.

AbstractThe Burnout Syndrome (SB) stems from the chronic emotional stress experienced by the worker, characterized by emotional exhaustion, depersonalization and low personal accomplishment. May involve professionals whose work relates directly to the public. Aims to assess the prevalence of SB and associated factors in higher education professionals, linked to the Primary Care Network Health in the city of Aracaju / SE, who answered the sociodemographic questionnaire and the Maslach Inventory for Burnout. The average age was 44.9 years, most nurses, women, married with children and graduate. The prevalence of SB was 6.7% to 10.8%, associated factors were younger age, excessive hours of work and job dissatisfaction. There was no difference between the categories evaluated and the majority does not have the SB. However, 54.1% had a high and moderate risk of developing this syndrome, reflecting a process of illness that threatens the welfare of top-level professionals from the Primary Care Network Health Aracaju - SE. These findings point to the importance of adopting preventive and interventional measures as collateral for a better working environment.

Research of primary hyperhidrosis in students of medicine of the State of Sergipe, Brazil

AbstractBACKGROUND:Hyperhidrosis or excessive sweat production occurs at 2.9-9% of the population.OBJECTIVE:To estimate the prevalence and disorders due to primary hyperhidrosis (HP) in medicine students in the state of Sergipe.METHODS:Cross-sectional study using individual interviews.RESULTS:Hyperhidrosis was found in 14.76% of subjects, the most affected regions were palmar, plantar and axillary, causing prejudice in daily activities. Family history occurred in 45% and 22.72% was diagnosed by a physician.CONCLUSION:The prevalence of hyperhidrosis in medicine students of Sergipe was high, with strong family and a small portion of diagnoses made by medical professionals.

Avaliação epidemiológica das vítimas de trauma abdominal submetidas ao tratamento cirúrgico / Epidemiological evaluation of abdominal trauma victims submitted to surgical treatment

OBJETIVO: avaliar o perfil epidemiológico e o desfecho das vítimas de trauma abdominal submetidas à laparotomia em hospital de urgência. MÉTODOS: estudo observacional, descritivo, longitudinal, com abordagem prospectiva, mediante entrevista de 100 pacientes com trauma abdominal submetidos ao tratamento cirúrgico e à avaliação dos seus prontuários. Período da coleta dos dados: setembro a novembro de 2011. RESULTADOS: Os pacientes mais acometidos pelo trauma abdominal foram do sexo masculino, de cor parda, na faixa etária de 25-49 anos, com baixa escolaridade, solteiros, católicos, com rendimento de um a dois salários mínimos. Houve uma predominância do trauma no ambiente urbano, no período noturno e no final de semana. O motivo mais frequente do trauma foi a tentativa de homicídio, associado ao uso de álcool e drogas ilícitas e o mecanismo a arma branca. A dor mostrou-se o sinal de alerta mais presente. A região mais afetada foi abdome superior e o fígado o órgão mais acometido. O tempo de internação hospitalar durou em torno de quatro a dez dias. A maioria teve alta sem sequela. Ocorreram dois óbitos. CONCLUSÃO: Foi marcante a associação do trauma abdominal com homens sob efeito de álcool e/ou drogas ilícitas, refletindo o contexto da violência interpessoal na sociedade atual. A despeito da magnitude do trauma, o desfecho foi satisfatório, apesar da ocorrência de óbitos, o que denota a importância dos hospitais de urgência de manter no seu corpo clínico uma equipe cirúrgica treinada.

OBJECTIVE: To evaluate the profile and outcome of victims of abdominal injuries who underwent laparotomy in the Emergency Hospital of the state of Sergipe (HUSE). METHODS: This was an observational, descriptive longitudinal study with prospective approach, through interviews of 100 patients with abdominal trauma who underwent surgery and evaluation of their medical records. The study period was from September to November of 2011 in the area of trauma care of the HUSE. RESULTS: the most affected individuals were male, mulattos, aged 25-49 years, with low education, single, Catholic, with an income of 1-2 minimum wages. There was a predominance of trauma in the urban areas, at night and on weekends. The most frequent cause of trauma was the attempted of murder associated with the use of alcohol and illicit drugs, and the most frequent mechanism, stabbing. The pain was the most frequent symptom. The most affected region was the upper abdomen and liver was the most affected organ. The hospital stay averaged 4-10 days. Most patients were discharged without sequelae. There were 2 deaths. CONCLUSION: In the HUSE, the association of abdominal trauma with men under the influence of alcohol and illegal drugs was striking, reflecting the context of interpersonal violence in current society. Despite the magnitude of the traumas, the outcome was satisfactory, although deaths, occurred, demonstrating the importance of keeping a trained surgical team in emergency hospitals.